Products
ZEB1 antibody
- Product Name
- ZEB1 antibody
- Catalogue No.
- FNab09620
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- zinc finger E-box binding homeobox 1
- Alternative Names
- AREB6 antibody, BZP antibody, DELTA EF1 antibody, delta EF1 antibody, antibody, Negative regulator of IL2 antibody, NIL 2 A antibody, NIL 2 A zinc finger protein antibody, NIL 2A antibody, NIL2A antibody, TCF 8 antibody, TCF8 antibody, Transcription factor 8 antibody, ZEB antibody, ZEB1 antibody, ZFHEP antibody, ZFHX1A antibody
- UniProt ID
- P37275
- Observed MW
- 210 kDa
Application
- Tested Applications
- ELISA, WB, IP,IHC
- Recommended dilution
- WB: 1:500-1:5000; IP: 1:200-1:2000；IHC: 1:500-1:5000
Validated Images
MCF7 cells were subjected to SDS PAGE followed by western blot with FNab09620(ZEB1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab09620(ZEB1 Antibody) at dilution of 1:1000
- Background
- Acts as a transcriptional repressor. Inhibits interleukin-2(IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition(EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box(5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa. This is a rabbit polyclonal antibody raised against part of the full length of ZEB1 of human.
